Neuropathic-like pain in knee osteoarthritis: exploring differences in knee loading and inflammation. A cross-sectional study

Key Points

1. Patients with indication of neuropathic-like pain exhibited a significantly higher KAM impulse (an estimate of dynamic medial knee joint loading) compared to those with no indication of neuropathic-like pain.

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BACKGROUND & OBJECTIVE

The estimated prevalence of neuropathic-like pain in patients with knee osteoarthritis (OA), defined by self-administered questionnaires, ranges from 20-40% (1). Patients with knee OA with neuropathic-like pain tend to describe their pain using descriptors such as burning, numbness, itching and electric shocks (1). Mechanical knee loading and inflammation are important factors associated with the pain experience in patients with knee OA (2). However, little research has explored potential differences in knee loading and inflammation in this patient subgroup.

Therefore, the aim of this cross-sectional study was to explore differences in inflammation and knee loading in patients with knee OA with neuropathic-like pain.

The estimated prevalence of neuropathic-like pain in patients with knee osteoarthritis ranges from 20-40%.

The presence of neuropathic-like pain in patients with knee OA may have implications for management in clinical practice.

METHODS

• This cross-sectional study analyzed data from 96 patients (mean age: 64.18±7.11 years, 53% female, mean BMI: 28.3±3.7 kg/m²) with knee OA.

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