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Home-based intervention to prevent functional decline in (pre)frail older adults: the PromeTheus randomized controlled trial

Review written by Dr Mariana Wingood info

Key Points

  1. About half of the older-adult population is pre-frail or frail, which has the potential of being reversed with appropriately dozed physical activity or exercise programs.
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BACKGROUND & OBJECTIVE

Approximately 50% of older adults are pre-frail or frail, meaning that they experience reduced physiological reserves and increased vulnerability to adverse outcomes such as disability, hospitalization, and mortality (1). Current care models rely heavily on episodic physiotherapy or costly inpatient services, which are often insufficient, unsustainable, or undesirable for older adults who prefer to age in place, highlighting the need for more comprehensive community-based approaches (1). Evidence supports multifactorial interventions that include exercise, nutrition, psychosocial support, and environmental modifications. These interventions are effective strategies for preventing or reducing frailty (1).

Therefore, the PromeTheus program was developed as a 12-month, interdisciplinary, home-based intervention delivered through existing primary care resources, but knowledge on its impact on frailty is limited. The objective of this study was to examine the effectiveness of a home-based, multifactorial, interdisciplinary intervention that aims to prevent functional and mobility decline in older adults who are pre(frail).

Approximately 50% of older adults experience reduced physiological reserves and increased vulnerability to adverse outcomes such as disability, hospitalization, and mortality.
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Physical frailty addressed with appropriately dosed exercise that aligns with the exercise prescription outlined above and is measured with a tool that assesses these frailty-components, can be reversed.

METHODS

Design: A multicenter randomized controlled trial.

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