A systematic review of inflammatory cells and markers in human tendinopathy

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Review written by Tom Goom

Key Points

  1. A systematic review of inflammatory cells and markers in tendinopathy was completed and included 53 studies.
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BACKGROUND & OBJECTIVE

For some time, the pathology of tendinopathy has been considered one of degenerative change with an absence of inflammation. As a result, the suffix ‘itis’ has long been omitted to reflect this change in thinking. However, some research groups have challenged this and even suggested that inflammatory changes may explain the presence of pain in tendinopathy, which isn’t well accounted for in some current models (1). This study sought to determine the role of inflammation by reviewing the research on inflammatory cells and markers in tendinopathy.

The pathology of tendinopathy in recent times has been considered one of degenerative change with an absence of inflammation.
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Inflammation may be a much more significant part of the clinical picture than previously thought.

METHODS

A systematic review was conducted which included 53 studies and a total of 2306 tendinopathic tendon specimens. To be included, studies needed to be level 3 evidence or above and could be cross-sectional, case-control, prospective observational studies or randomized controlled

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